Muscle Wasting Disorders
Muscle wasting, also known as muscle atrophy, is the loss of muscle mass and strength. Several factors, including disease, lack of use, injury, extended immobilization, malnutrition, neurogenic conditions, and aging can cause it.
ICU Related Conditions
Mechanical ventilation (MV) is a life-saving intervention, however:
- Patients can lose up to 30% of muscle mass in a week.
- Prolonged MV leads to a variety of myopathies, which increase ICU stays for millions of patients per year, costing health systems tens of billions1 and leading to higher mortality and morbidity rates.
- MV usage is also associated with other iatrogenic complications.2
Leksum has the only proven solution to the muscle wasting problem in ICUs that restores muscle mass and function – a first!
Aging and Cancer
Aging is a significant cause of muscle loss (sarcopenia).
Muscle loss can begin as early as age 40, with as much as half of muscle mass lost by age 70.
The Leksum pipeline includes products developed to address muscle wasting caused by old age and cancer cachexia. The company will continue product development in these muscle wasting domains.
Weight Loss Medications
When people lose large amounts of weight in a short time, the loss of muscle mass can be drastic.
Upto 30% of the weight patients lose on GLP-1 drugs may actually be due to decrease in lean muscle mass.
The Leksum scientific team will employ Leksum’s Muscle Regeneration Platform to resolve the potential muscle loss caused by weight loss medications. As the use of GLP-1 drugs increases, addressing muscle loss will become an even greater issue.